Journal: J Infect Dis
Lead Author: Skowrosnki, et al.
Original date of publication: 04/01/2017
Link: https://pubmed.ncbi.nlm.nih.gov/28180277/
Keywords: antigenic distance hypothesis; antigenic site.; genomic sequencing; hemagglutination inhibition; influenza A(H3N2) subtype; negative interference; repeat vaccination; vaccine effectiveness.Canadaeffectivenessfluinfluenzaseasonal influenza vaccinevariants
Full Author List: Danuta M Skowronski, Catharine Chambers, Gaston De Serres, Suzana Sabaiduc, Anne-Luise Winter, James A Dickinson, Jonathan B Gubbay, Kevin Fonseca, Steven J Drews, Hugues Charest, Christine Martineau, Mel Krajden, Martin Petric, Nathalie Bastien, Yan Li, Derek J Smith
Lead Author: Skowrosnki, et al.
Original date of publication: 04/01/2017
Link: https://pubmed.ncbi.nlm.nih.gov/28180277/
Summary Context
The antigenic distance hypothesis (ADH) is explored in this research, suggesting that closer strains in the shots generate better outcomes for flu vaccination.
Comments
The researchers in this study discuss why the flu vaccine campaigns in Canada are generally not effective.
Abstract or Results, Key Passages
” Effects of repeat influenza vaccination were consistent with the antigenic distance hypothesis and may have contributed to findings of low effectiveness across recent A(H3N2) epidemics since 2010 in Canada.”
Keywords: antigenic distance hypothesis; antigenic site.; genomic sequencing; hemagglutination inhibition; influenza A(H3N2) subtype; negative interference; repeat vaccination; vaccine effectiveness.Canadaeffectivenessfluinfluenzaseasonal influenza vaccinevariants
Full Author List: Danuta M Skowronski, Catharine Chambers, Gaston De Serres, Suzana Sabaiduc, Anne-Luise Winter, James A Dickinson, Jonathan B Gubbay, Kevin Fonseca, Steven J Drews, Hugues Charest, Christine Martineau, Mel Krajden, Martin Petric, Nathalie Bastien, Yan Li, Derek J Smith
