antigenic distance hypothesis; antigenic site.; genomic sequencing; hemagglutination inhibition; influenza A(H3N2) subtype; negative interference; repeat vaccination; vaccine effectiveness. Archives

Serial Vaccination and the Antigenic Distance Hypothesis: Effects on Influenza Vaccine Effectiveness During A(H3N2) Epidemics in Canada, 2010-2011 to 2014-2015

The antigenic distance hypothesis (ADH) is explored in this research, suggesting that closer strains in the shots generate better outcomes for flu vaccination.