Lead Author: Carlin, JB et al.
Original date of publication: 11/01/2013
Link: https://pubmed.ncbi.nlm.nih.gov/23964090/
Summary Context
Authors found a relative risk of almost 7 times the risk of bowel intussusception after Rotarix injection, with a sustained significant risk after the second dose as well. In their second analytical approach, the risk was 15x increase in the event in the week after the first dose.
Comments
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This review of the data from Australia’s national vaccine program shows a high (7x to 15x) increase in rates of hte severe side effect of bowel intussusception in kids after rotavirus injection. Predictably, the authors downplay the signficance of this life-threatening side effect.
Abstract or Results, Key Passages
” Based on 306 confirmed cases of IS, the relative incidence of IS in the 1-7-day period after the first vaccine dose, was 6.8 (95% confidence interval, 2.4-19.0; P < .001) for RV1, and 9.9 (95% confidence interval, 3.7-26.4; P < .001) for RV5. There was a smaller increased risk 1-7 days after the second dose of each vaccine. The case-control analysis gave similar results. We estimate an excess of 14 IS cases and >6500 fewer gastroenteritis hospitalizations in young children annually in Australia after vaccine introduction.”
Keywords: adverse eventsFDA studyIntussusceptionrotarixrotavirusrotavirus vaccine
Full Author List: John B Carlin 1, Kristine K Macartney, Katherine J Lee, Helen E Quinn, Jim Buttery, Ruth Lopert, Julie Bines, Peter B McIntyre
