Infectious etiologies of intussusception among children less than 2 years old in 4 Asian countries

Journal: J Infect Dis
Lead Author: Burnett E, et al.
Original date of publication: 04/01/2020
Link: https://pubmed.ncbi.nlm.nih.gov/31754717/

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Summary Context

This study showed that wild-type rotavirus infection does not cause the dangerous side effect associated with the two rotavirus injections– bowel intussusception. It also shows it may be protective against the event.

Comments

This study conducted in Bangladesh, Nepal, Pakistan, Vietnam found that rotavirus infection from wild-type virus did not result in bowel intussusception, a well-known dangerous side-effect of rotavirus vaccination. It even showed a potentially protective effect against it.

Abstract or Results, Key Passages

“In this comprehensive evaluation, adenovirus and HHV-6 were associated with intussusception. Future research is needed to better understand mechanisms leading to intussusception, particularly after rotavirus vaccination.”

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Keywords: adverse eventsIntussusceptionnatural infectionrotavirusrotavirus vaccine

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Full Author List: Eleanor Burnett, Furqan Kabir, Nguyen Van Trang, Ajit Rayamajhi, Syed M Satter, Jie Liu, Mohammad Tahir Yousafzai, Dang Duc Anh, Anupama Thapa Basnet, Meerjady S Flora, Eric Houpt, Saqib Hamid Qazi, Tran Minh Canh, Anjana Karki Rayamajhi, Bablu K Saha, Nasir Saleem Saddal, Sehrish Muneer, Pham Hoang Hung, Towhidul Islam, Syed Asad Ali, Jacqueline E Tate, Catherine Yen, Umesh D Parashar