Journal: Vaccine
Lead Author: Fraiman, et al.
Original date of publication: 08/01/2022
Link: https://pubmed.ncbi.nlm.nih.gov/36055877/
Keywords: adverse eventsclinical trialsModernamRNAPfizersevere adverse eventsside effectsvaccine side effects
Full Author List: Joseph Fraiman, Juan Erviti, Mark Jones, Sander Greenland, Patrick Whelan, Robert M Kaplan, Peter Doshi
Lead Author: Fraiman, et al.
Original date of publication: 08/01/2022
Link: https://pubmed.ncbi.nlm.nih.gov/36055877/
Summary Context
This study shows that both mRNA vaccine platforms are associated with an increased risk of serious adverse events over baseline rates.
Comments
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This study reviewed a priority list of serious adverse events and investigated the Pfizer and Moderna clinical trial documents accordingly, and found an increased association above baseline of 101 serious events per 100,000 among vaccinated for Pfizer and 151 per 100,000 among those who took the Moderna shot.
Abstract or Results, Key Passages
“The excess risk of serious adverse events found in our study points to the need for formal harm-benefit analyses, particularly those that are stratified according to risk of serious COVID-19 outcomes. These analyses will require public release of participant level datasets.”
Keywords: adverse eventsclinical trialsModernamRNAPfizersevere adverse eventsside effectsvaccine side effects
Full Author List: Joseph Fraiman, Juan Erviti, Mark Jones, Sander Greenland, Patrick Whelan, Robert M Kaplan, Peter Doshi
