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Intracellular reverse transcription of Pfizer human liver cell line

Journal: Current Inssues in Molecular Biology
Lead Author: Alden, et al.
Original date of publication: 02/01/2022
Link: https://www.researchgate.net/publication/359084279_Intracellular_Reverse_Transcription_of_Pfizer_BioNTech_COVID-19_mRNA_Vaccine_BNT162b2_In_Vitro_in_Human_Liver_Cell_Line#fullTextFileContent

Summary Context

This study shows how the Pfizer mRNA vaccine has the apparent capacity to integrate into the genome of human cells.

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This landmark study is the first to generate evidence in human liver cell lines showing how the Pfizer vaccine enters and reverse transcribes into DNA.

Abstract or Results, Key Passages

“Our results indicate a fast up-take of BNT162b2into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. We alsoshow that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h uponBNT162b2 exposure (PDF) Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. Available from: https://www.researchgate.net/publication/359084279_Intracellular_Reverse_Transcription_of_Pfizer_BioNTech_COVID-19_mRNA_Vaccine_BNT162b2_In_Vitro_in_Human_Liver_Cell_Line#fullTextFileContent [accessed Nov 24 2025].”

Keywords: adverse eventsreverse transcriptioncovid vaccinationDNA integrationmRNAPfizer
Full Author List: Markus Aldén , Francisko Olofsson Falla, Daowei Yang, Mohammad Barghouth, Cheng Luan ,Magnus Rasmussen, Yang De Marinis