Lead Author: Nakao Ota, et al
Original date of publication: 06/01/2025
Link: https://www.sciencedirect.com/science/article/pii/S096758682500195X
Summary Context
Japanese scientists published a recent study showing new evidence of COV-19 mRNA vaccine spike protein persisting in cerebral arteries of 43.8% of haemorrhagic stroke patients up to 17 months post-vaccination with absence of infection, expressing concerns about vaccine biodistribution and long-term safety.
Comments
This recent study reviews the safety of mRNA inoculations. The expression of spike protein in the cerebral arteries of 43.8% of haemorrhagic stroke patients up to 17 months post-vaccination suggests serious implications for hemorrhagic stroke post-mRNA vaccination. The study raises concerns regarding the biodistribution of lipid nanoparticle-based vaccines and their long-term safety.A limitation of the study was the small sample size with only 19 subjects. Within the narrative of the study certain implied assumptions should be noted and challenged- for example, “The rapid deployment of mRNA vaccines provided a critical tool in combating the COVID-19 pandemic.” The results of this study call for further research to validate or repudiate these findings and ensure comprehensive safety evaluations of mRNA vaccines.
Abstract or Results, Key Passages
Conclusion: Although the possibility of spike protein expression due to asymptomatic SARS-CoV-2 infection cannot be entirely excluded, this study demonstrated prolonged presence of SARS-CoV-2 spike protein in the cerebral arteries following mRNA vaccination. Additionally, some inflammatory cell infiltration was observed in spike-positive vessels. These findings raise significant concerns regarding the biodistribution of lipid nanoparticle-based vaccines and their long-term safety. Global replication studies are urgently required to validate these findings and ensure comprehensive safety evaluations of mRNA vaccines.”
Keywords: adverse eventscovid vaccinationmRNASpike protein
Full Author List: Nakao Ota, Masahiko Itani, Tomohiro Aoki, Aki Sakurai, Takashi Fujisawa, Yasuaki Okada, Kosumo Noda, Yoshiki Arakawa, Sadahisa Tokuda, Rokuya Tanikawa
